Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F.Food and Drug Administration (FDA) accelerated approval of the pembrolizumab combination for the first-line treatment of patients with locally advanced unresectable or metastatic HER2+ gastric or gastroesophageal junction adenocarcinoma. The initial findings of KEYNOTE-811, that were selected to first outing during the 2021 Annual Meeting of the American Society of Clinical Oncology – ASCO (04 - 08 June), led to the subsequent U.S. “While these results are promising, the completion of this clinical trial will confirm whether our data translates in improved progression-free survival as well as overall survival,” added Josep Tabernero, Head of the Medical Oncology Department, Vall d’Hebron University Hospital (HUVH, Barcelona, Spain). Not only did the combination of pembrolizumab, trastuzumab, and chemotherapy significantly improve objective response rate, it also markedly reduced tumor size and induced complete responses in some patients,” said co-author, Josep Tabernero. “This study is the first to show the efficacy of a PD-1 immune checkpoint inhibitor in this particular patient population. Published today in Nature (2), the KEYNOTE-811 Investigators including VHIO’s Director, Josep Tabernero, report results from the interim analysis of the first 264 patients who were randomly assigned 1:1 to receive pembrolizumab or placebo in combination with trastuzumab and chemotherapy.ĭata show that the objective response rate was 74.4% in the pembrolizumab arm and 51.9% in the placebo arm, which represents a 22.7% improvement versus trastuzumab and chemotherapy, and supports preclinical data suggesting a possible synergy between dual HER2 and PD1 blockade. Janjigian, Chief of the Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center (MSKCC, New York, USA), was designed to further assess this novel triplet combination in this patient population. Previous phase II studies combining PD-1 antibody pembrolizumab with trastuzumab and chemotherapy have shown increased clinical efficacy and a manageable safety profile in patients with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma.īuilding on these encouraging results, the randomized, double-blind, global phase III KEYNOTE-811 trial, led by Yelena Y. KEYNOTE-811: ringing in IO-based therapy for HER2+ gastric cancer For over a decade, the combination of anti-HER2 antibody trastuzumab and chemotherapy has constituted the standard first-line treatment for patients with HER2-positive disease. Ranking fifth for cancer incidence and fourth for cancer mortality, with an estimated 769,000 deaths globally in 2020, this tumor type represents a major healthcare challenge.Īpproximately 20% of advanced gastric and gastroesophageal junction cancers have overexpression or amplification of human epidermal growth factor receptor 2 ( HER2), which associates with a poor prognosis and increased disease recurrence and mortality. This study, upon completion, could lead to a paradigm shift in the treatment of patients with locally advanced unresectable or metastatic HER2+ gastric or gastroesophageal junction adenocarcinoma.Īccording to a recent report (1) gastric cancer is responsible for over one million new cases worldwide in 2020, with an increasing incidence among young adults (aged <50 years). Published in Nature, results of the interim analysis show that this novel triplet combination markedly reduces tumor size, induces a complete response in some patients, and significantly improves objective response. Image: Josep Tabernero, Director, Vall d'Hebron Institute of Oncology (VHIO), Head, Medical Oncology Department, Vall d'Hebron University Hospital (HUVH), Barcelona, Spain view moreĬredit: Vall d'Hebron Institute of Oncology Initial findings of the phase III KEYNOTE-811 trial of pembrolizumab plus trastuzumab and chemotherapy -first presented at ASCO 2021- led to the subsequent FDA approval of this combination for the first-line treatment of patients with HER2+ gastric cancer.
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I am not a fan of keyboard warriors but it is also not easy for a working class guy to have a major say in affairs back home. We don’t like to write negative blogs but sometimes you are forced and need to vent somewhere. Where did all the money go? I for one didn’t buy a large house, I didn’t buy property in Bulgaria and I didn’t collect any brown envelopes, except for bills. The Celtic Tiger roared and supposedly we all had a great time, yes undoubtedly some did, but not all. A greedy, unjust society where our young have little or no chance of owning their own home and the old who have worked all their lives are forced to work longer for reduced pensions. It is only now in adulthood that I have a true appreciation of the cause that was fought back then and why these men sacrificed their lives to make Ireland an independent free nation, one hundred years on these men would be turning in their graves if they could see what the nation has become. History book after history book placed in front of us when all we wanted to do was be at home. As a child and teenager I think it is safe to say that the majority of my classmates really didn’t appreciate the significance of these people or places. As an Irishman I grew up listening to and reading stories in school about Connolly, Pearse and Plunkett and walking through the streets of Dublin was aware of the significance of the GPO, Kilmainham Gaol and Portobello Bridge, to name but a few. This year marks an important milestone in our nation’s history, the one hundredth anniversary of the 1916 Rising. My Irish Shame.Emigration, Evictions and the EU. Why My Irish Shame in the title? Read on to find out. How can we travel through much of the developing world and comment that these people are not poor? It is us from the developed world who are poor which can be said for my home country. 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Introduction: The study of microbial communities based on the combined analysis of genomic and proteomic data – called metaproteogenomics – has gained increased research attention in recent years. ♦ this Male TRS ↔ Female TRRS adapter for mics: (converts TRRS mics like SmartLav+ into TRS mics, making them compatible with smartphones → cameras) equivalent to the Rode adpter : ♦ TRS & TRRS 3.5 male² cables TRS cable cut on 1 hand for experiments ♦ Android phone (Galaxy S10e), with 3.5 hp jack High Res Audio Recorder & Call apps ♦ Focusrite Scarlett USB Interface, with XLR 48V mic & I don't want wireless apps like Airdroid, wire = no data spying, best quality + reliability, - battery drains, & no Wi-Fi required in order to work (I actually have no Wi-Fi □). Couldn't use apps through Windows PC either the "My phone" Windows App was supposed to allow that, but it never worked for me & seems so unreliable anyway (Force close all the time, ppl saying it cancels calls randomly.) Samsung Dex is also an app very close from achieving it (it probably could in the future?), but the feature is just not available, only audio Phone→PC is supported. Of course, I came to that idea, since I couldn't make the USB interface work on the smartphone, for every mic usage, notably rec & calls. □Goal : Transforming the Direct Monitoring Output of the Focusrite into a Mic input (so that I don't need any numerical compatibility between devices, such as USB, drivers, etc), allowing to use any mix plugged into the interface, including 48V/Phantom power ones, on any device, 100% analogically. But I'll still detail what I tried, so that anyone willing to push it further, would have - to try out. Unfortunately, didn't find any way to make it work. What you guys are trying to achieve, in right on point with the testings on my side. Also, my mic is being force-fed back into usb headphones, with no ways to turn it off.Ĭ'mon guys i feel i'm so close!!! all ideas welcome to complete the final step! instead my phone could not receive any audio from my pc. Theoretically, now tick "listen to device" for mic on usb headphones and use default speaker as listen output everything should work, but it doesn't. make a sound on phone (open a video, play music etc), and will hear it on usb headphones. on pc open sound settings and open property for default microphone, tick "listen to device", and use usb headphones as listen output. now unplug the splitter from pc and switch them around, plug it back in. phone will recognize that headphones has been plugged in (my phone shows a small headphones symbol at the top of the screen). connect type-c to phone, 3.5mm to splitter, and splitter normally to pc. but i could not pass audio from pc to phone. well guess what mods it IS possible and i have solved half of the puzzle! there was also a new reply (when i saw it, it said posted 5 minutes ago) but it got deleted and the thread marked solved. The original discussion was about if using pc as an external audio input/output source for android smartphone possible. Please cancel the subscription at least 24 hours before the current period ends.I was replying to an 2018 thread by mltco78dhs but by the time i finished writing it became "solved", with the "solution" being "nope you can't do that duh" and i thought that's not good enough. Subscription will be charged and auto-renewed in 24 hours based on your purchased type.Ĥ. Remote Support subscription will be charged to your iTunes account.ģ. **Remote Support Auto-renew Subscriptions**Ģ. In addition, you can make a voice call to them to have better communication. Once the connection succeeded, tap the button to invite your friend or parents to share their screen, and you can directly view their phone's screen in real-time.ĭuring the whole remote support process, you can text in the chatbox or send voice messages to your family or friend. You can connect your friend or family simply by their 9-digit Connection Code. Quick Connection by 9-digit Connection Code On AirDroid Remote Support, you can see a 9-digit connection code enter it on AirMirror and you are in connection.ġ. For the person who needs help, please download the controlled end app, AirDroid Remote Support.ģ. If you are the helper, please install this app: AirMirror.Ģ. With AirMirror, you can directly see the other phone’s screen on your iOS device while talking to them in real-time, helping you find and solve problems free from the hassle.ġ. Have you ever experienced wasting lots of time, trying to explain some simple settings through a phone call, but still failed to solve your parents or friend's phone issue?įrom now on, you can have an easier remote support solution: AirMirror The TDM400 that I am using is a working card, as is the machine that it is in. If you have found that your TDM400 works, likewise love to hear from you. If anyone has a digium TDM400 and can test with 1.4.1Beta, it would be appreciated to turn this report into a confirmed report. The fault is exactly identical to my issue, yet I have a Genuine Digium TDM400 card. They submitted a Bug to Digium, but basically they blew it off, not supporting A400 cards. Incoming calls work perfectly, but outgoing calls fail with the following message:Īpp_dial.c: Unable to create channel of type 'ZAP' (cause 0 - Unknown)įurther Info: It appears that this is not an Elastix issue with PIAF also showing similar problems Issue: The TDM400 shows up as configured, Zap show channels and Dahdi show channels shows the channels configured. Add that to the number of clones out there which will also suffer the same issue. Now fair enough, these cards are becoming End of Life, but there are literally thousands and thousands of them out there. After performing more tests, it appears that there is a problem with the TDM400 card. There is a major issue with the 1.4.1 Beta. Re:Elastix 1.4 Beta ready for Download - ISSUE! Based on this install I have moved this PBX into production use for the time being to put under further test. If the only error to report is a couple of icons missing, then there is not too much to worry about. On the whole, so far, one of the best and smoothest installs, and thats not bad for a beta. Only one minor comment on the Embedded Freepbx, the small icons are not showing up next to Delete Extension and Add Follow Me which are & Note this is extremely minor. Extension added successfully with no errors and extension working, confirmed it was visible via Unembedded Freepbx without any errors. Performed YUM update - looks good - no errorsĬomment: Good - Elastix now using Zaptel 1.4.12.1 (should correct a few recent wctdm24xxp detection issues)Īll system config was rebuilt by hand via unembedded Freepbx, however, as a test also added one extension via Embedded Freepbx. Will continue testing, but everything works as per 1.3-2 ElastixĮxcept Checked FOP - aghast!!! - FOP is showing up ZAPTEL trunks.:woohoo: Performed Module Install (for modules not installed by default)Ĭomment: No errors reported by install processĬhecked Freepbx System Status - All clear.no errors to report having seen this issue before where 16Mb was not enough.Ĭomment: All looked good - no errors reported by upgrade process Detected TDM400 ok.įreepbx changed my php setting immediately to 100Mb from 16Mb (automatic)Ĭomment: Good. Installation ok with no errorsĬomment: Like the clean interface of the hardware detection. # use with wideband codecs, 8000 for traditional codecs.Have installed 1.4-1 Beta on a machine with TDM400. 0 for atuomatic detection per channel/call, 16000 for # $intkey (can be any digit from 0 to 9 or # and *, or a combination of them) # $timeout (value in seconds of silence before recording is stopped) Values bigger than 0.95 usually mean that the # confidence : A value between 0 and 1 indicating how 'confident' the recognition engine # The scripts sets the following channel variables: # returned text string is assigned as the value of the channel variable 'utterance'. # The recorded sound is send over to googles speech recognition service and the # back to the user to indicate the start of the recording. If NOBEEP is set, no beep sound is played # interrupt key (# by default) is pressed. # (this can be set by the user by the 'timeout' argument, -1 for no timeout) or the # Records from the current channel until 2 seconds of silence are detected # the GNU General Public License Version 2. # This program is free software, distributed under the terms of # Copyright (C) 2011 - 2014, Lefteris Zafiris # AGI script that renders speech to text using Google's Speech API. Read the code, the istructions are at the top Been going crazy trying to figure this out, any help will be greatly appreciated.Įxten => s,n,agi(googletts.agi,"Please say one, plus the number you want to dial, followed by the pound sign",en)Įxten => s,n(record),agi(speech-recog.agi,en-US)Įxten => s,n,GotoIf($["$") How would I go about having the following dialplan work without requiring that # be pressed after the user says the number they want to dial? I see some vague references to this, but I am unsure how to go about implementing it. I have a question regarding the Asterisk speech recognition that uses the Google API. How that occurred was because I always wanted to be a saxophone player. “All my life I wanted to sound like myself, I never wanted to sound like anybody else. He said he wanted to “sing mellow – silky like butter” and was heavily influenced by female jazz singers, such as Nina Simone, Carmen McRae and Nancy Wilson, but his biggest influence was Ms. Billy had a unique smooth soul vocal style, and a versatility that took in mellow, falsetto and bottom register raspy. His debut album, Feelin' Good at the Cadillac Club dropped in 1968 the first of 15 albums he released up to ’88.īorn Paul Williams on December 1st 1935, he was one of the artists associated with the Philadelphia “Philly Sound” soul style, created by Kenny Gamble, Leon Huff, and Thom Bell. Jones." He began his long career in jazz clubs where such icons as Charlie Parker, Nina Simone and Miles Davis were plying their trade at the time. Paul is perhaps best known for his Grammy-award winning 1972 hit, "Me and Mrs. Paul's manager told a US TV station NBC10 that he died at his home in Blackwood, New Jersey, after being diagnosed with cancer, and had been hospitalized a week ago at Temple University Hospital in Philadelphia. “Please share you thought, messages and stories of Billy as we remember this legendary artist, family member and friend.” Billy will be truly missed." Fans were urged to share their stories of Billy. We would like to extend our most sincere condolences to his wife Blanche and family for their loss, as they and the world grieves the loss of another musical icon that helped pioneered today’s R&B music. "We regret to announce with a heavy heart that Billy has passed away today at home after a serious medical condition. The singer's death was announced on his website with a brief statement. Best known for the timeless classic global smash hit, “Me And Mrs Jones,” he died on Sunday (April 24th) due to pancreatic cancer. Philly sound soul legend Billy Paul has died. By Megan Barber Updated Dec 14, 2017, 3:21pm EST.You need to start with a ready-made solution, a house kit, which has been designed and tested. Note we do not recommend to build the house from scratch (that'd be a suicidal mission). Once you know what you want to build, pick a house kit model. Compare the quality of our structures, the premium quality of our materials. Choose from a variety of painted trim colors that come with our never-fade warranty. 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We've been dancing with the devil way too long The people posting the “black flag” videos on TikTok appear primarily to use two different pieces of music as accompaniment: The first, “Raise the Colors,” is a gloomy sea shanty from Pirates of the Caribbean 2 the second, the song “God We Need You Now” by country rapper Struggle Jennings and cowriter Caitlynne Curtis, features QAnon-derived lyrics that threaten retribution for the people who “desecrate” the “values of our country and our God”: Both battles are considered Confederate atrocities. Its use in the Civil War primarily appears to have been featured in some of the heinous massacres of Black Union soldiers in the war, notably at the Battle of the Crater and at Fort Pillow. The same flags have been showing up on people’s home flag displays as well, as Michelle Davis of Living Blue Texas observed in a post headlined, “Are Your Republican Neighbors Planning On Killing You?” Primarily, videos of people erecting these flags on the fronts of their homes are being widely shared on social media, particularly TikTok and Facebook Davis reported finding hundreds of them.īlack flags have a particular historical meaning for Americans: They first appeared on Civil War battlegrounds, carried by some Confederate Army units, and symbolizing the intent of the soldiers to neither seek any quarter nor give any-essentially, the opposite of the white flag of surrender, signifying that enemy combatants are to be killed rather than taken prisoner. Another one turned up when the protest moved to Riverfront Park. The black flags have been showing up at various right-wing protests, such as last weekend’s “Health Freedom Rally” in Spokane, Washington-really a low-turnout affair mainly comprised of anti-vaccination protesters standing on a street corner, waving flags. People flying them are essentially signaling that they’re prepared to kill their liberal neighbors. “No quarter shall be given” is the black flag’s traditional message-and in the context of the building drumbeat of right-wing “civil war” talk, a deeply ominous one. Now, amid far-right protests against COVID-related vaccine and mask mandates, far-right extremists are unfurling their latest symbol: An all-black American flag, with stars and stripes mainly visible through variations in material and shading. In the past few years, the prominent use of flags by belligerent far-right Trump fans, particularly those in “Trump Trains” or participating in right-wing invasions of urban liberal centers, has ranged from basic Trump or MAGA banners to “Blue Lives Matter” flags to their most recent “Fuck Biden” iterations. The alt-right came up with its Naziesque “Kekistan” banner. First it was the yellow “Don’t Tread On Me” Gadsden flag flown by the Patriot movement and tea party. Far-right extremists over the years have adopted a number of flag designs as their representative banners. |
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